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MAC cervical adenitis is almost exclusively a disease of children, with most cases occurring in those under the age of 3 years.

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Coadministration of Clarithromycin with ranitidine bismuth citrate resulted in increased plasma ranitidine concentrations (57%), increased plasma bismuth trough concentrations (48%), and increased 14-hydroxy-Clarithromycin plasma concentrations (31%).

In a controlled clinical study of acute otitis media performed in the United States, where significant rates of beta-lactamase producing organisms were found, clarithromycin was compared to an oral cephalosporin.

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In patients randomized to clarithromycin, the risk of MAC bacteremia was reduced by 69% compared to placebo.

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Medicines are sometimes prescribed for conditions other than those listed in a Medication Guide.

Standard Clarithromycin powder should provide the following MIC ranges.

Clarithromycin-containing regimens should not be used in patients with known or suspected Clarithromycin resistant isolates because the efficacy of treatment is reduced in this setting.

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The recommended adult dose is 500 mg clarithromycin given three times daily (q8h) and 40 mg omeprazole given once daily (qAM) for 14 days.

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In the event of severe acute hypersensitivity reactions, such as anaphylaxis, Stevens-Johnson Syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms (DRESS), and Henoch-Schonlein purpura clarithromycin therapy should be discontinued immediately and appropriate treatment should be urgently initiated.

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Clarithromycin should be used in combination with other antimycobacterial drugs that have shown in vitro activity against MAC or clinical benefit in MAC treatment.

Improvement in daytime sleepiness with clarithromycin in patients with GABA-related hypersomnia: Clinical experience".

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